two a2m injection pictures

Alpha 2 Macroglobulin

A2M Injection

in Jacksonville, FL

An A2M injection offers a natural way to protect your joints from degeneration and chronic pain without relying on invasive surgery or extended medication use.
At Active Health, this regenerative treatment helps block the enzymes that break down cartilage, supporting joint health and relieving discomfort. Whether you're noticing early signs of osteoarthritis or recovering from a joint injury, A2M therapy is integrated into a strategic plan designed to reduce pain, slow deterioration, and promote long-term mobility.
Ready to explore a smarter, more targeted path to joint protection? Schedule an appointment today and start building a plan that supports lasting movement and joint health.

What is an A2M Injection?

A2M injection therapy uses a natural blood protein called alpha-2-macroglobulin to help protect cartilage and reduce inflammation inside the joints. This protein works by neutralizing enzymes that contribute to tissue breakdown and chronic discomfort.
The process starts with a small blood draw, which is then processed to concentrate the healing proteins. The final solution is injected into the targeted joint with guided precision, allowing the treatment to reach the source of irritation.
Because the protein comes from your own body, the therapy is well-tolerated and carries minimal risk. It’s a safe, non-surgical option for preserving joint integrity and supporting long-term mobility.
male patient being treated for knee and hip pain
A2M Therapy

Conditions an A2M Injection Can Help Treat

A2M being injected into a patient's knee
At Active Health, an A2M injection is part of a regenerative care system designed to preserve joint integrity, reduce inflammation, and support long-term mobility. It’s most effective when applied early and strategically for conditions involving cartilage breakdown or chronic joint irritation.
A2M injections help protect cartilage in arthritic joints by neutralizing destructive enzymes. Patients often experience reduced stiffness, less pain, and improved daily function.
Whether caused by early degeneration or overuse, an A2M injection supports healing and comfort in the knee joint, helping reduce inflammation and protect against further damage.
Chronic joint discomfort in the hips, shoulders, or ankles may benefit from an A2M injection, especially when other conservative approaches haven’t provided lasting relief.
In carefully selected cases, A2M may be used as part of a spinal injection protocol to calm disc-related inflammation and protect surrounding structures in the spine.
When pain originates from degenerative changes or joint inflammation, A2M can offer a non-surgical option to support spinal comfort and preserve mobility.
For active people recovering from joint sprains, overuse, or cartilage irritation, an A2M injection may help reduce recovery time and support long-term joint performance when combined with targeted rehab.
background

Advantages of an A2M Injection at Active Health

At Active Health, A2M injections are part of a comprehensive system, refined since 2005, and designed to deliver lasting results. Our goal is to protect your joints now and help you maintain an active lifestyle for years to come. Here’s what sets our approach apart:
Targets the Source of Degeneration
Instead of masking symptoms, this therapy addresses the underlying enzymes that contribute to cartilage damage and chronic inflammation.
Low-Risk, High-Impact
Because the solution comes from your own blood, treatment is well-tolerated and minimally invasive, with most patients returning to daily activities shortly after.
Aligned With Your Life
Your plan is personalized based on how you move, what you do, and what your goals are, not just where it hurts. Each step is guided by a functional evaluation and tailored to your routine.
Part of a Coordinated Strategy
We combine regenerative options like A2M with physical therapy, movement retraining, and advanced assessments. This keeps care connected and focused on lasting change.
an Active Health female patient touching her right elbow to her left knee while exercising

Why choose Active Health for A2M Injections?

At Active Health, A2M injections are part of a regenerative plan designed to reduce joint damage and support long-term performance, not just provide short-term relief.
We begin with a detailed evaluation of your movement patterns, daily demands, and tissue health. From there, we design a step-by-step plan that may include Alpha-2-Macroglobulin therapy, targeted rehabilitation, or other regenerative options based on your goals.
You’ll work with a coordinated team that understands how to sequence care for better outcomes. Whether you’re managing early osteoarthritis or trying to protect your joints from further damage, we help you take control of your progress with a plan that makes sense for your needs.
Build resilience from the inside out with joint care that goes beyond symptom management.

Play the Long Game of Health

Get ahead of pain with targeted, non‒invasive approaches designed for lasting results.
FAQs
What is Alpha-2-Macroglobulin?
Alpha-2-Macroglobulin, or A2M, is a natural protein in your blood that captures and neutralizes enzymes responsible for breaking down cartilage. By doing so, it helps reduce inflammation and protect joint structures from degenerative damage.
Is A2M FDA-approved?
A2M is not FDA-approved as a drug because it is a natural component of your own blood. However, the devices used to process and inject it are FDA-cleared, and the therapy is considered off-label. Many regenerative clinics use it safely to support joint health and pain relief.
Do A2M knee injections really work?
A2M knee injections can be effective for the right candidates. They may help slow cartilage degeneration, reduce inflammation, and improve comfort, especially in early to moderate osteoarthritis. Your provider will determine if A2M injections are appropriate for your condition.
What is A2M therapy?
A2M therapy is a regenerative treatment where a small sample of your blood is drawn, concentrated to isolate the Alpha-2-Macroglobulin protein, and then injected into a joint. This process helps protect cartilage, reduce inflammation, and relieve pain caused by arthritis or early degeneration.
client of Active Health playing tennis
Reach out to us

Reach Out To Us

This form should only be used for general information (ie don't send any detailed/personal health information via this form). All patient‒specific care questions should be addressed during your appointment.